Drug and alcohol dependence · 2026
Dezocine-mediated reversal of sufentanil-induced respiratory depression and its mitigation of adverse reactions: A clinical investigation.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Gui Yong-Kang, Liu Li-Fang, Shan Meng-Lei, Wang Jia-Wei, Yang Xiao, Da Xin, Xu Guang-Hong
Аннотация
BACKGROUND: Respiratory depression (RD) is the most life-threatening adverse reaction associated with opioid drug use. However, previous studies have found that partial opioid receptor agonists can effectively reverse RD induced by opioid drugs.
METHODS: Sixty eligible patients were randomly assigned to either the Dezocine group (group D) or the Control group (group C). Patients in group D were given sufentanil combined with dezocine (0.1mg/kg) within 10s. Patients in group C were given sufentanil combined with the same volume of normal saline. During intravenous administration, oxygen inhalation at 5L/min was also administered.
RESULTS: The RD ED50 in group D was 0.486μg/kg (95% CI: 0.411-0.546μg/kg), while that in group C was 0.293μg/kg (95% CI: 0.252-0.336μg/kg). RD occurred in 12 patients in group D and 14 patients in group C. RD in both groups was mainly characterized by a reduced respiratory rate. There were no significant differences in the incidence or types of RD within the first 5 and 10min after administration (P > 0.05). When RD occurred, percutaneous oxygen saturation in all patients remained above 98%.
CONCLUSIONS: Dezocine can partially reverse RD induced by sufentanil and increase the ED50 of RD induced by sufentanil.
METHODS: Sixty eligible patients were randomly assigned to either the Dezocine group (group D) or the Control group (group C). Patients in group D were given sufentanil combined with dezocine (0.1mg/kg) within 10s. Patients in group C were given sufentanil combined with the same volume of normal saline. During intravenous administration, oxygen inhalation at 5L/min was also administered.
RESULTS: The RD ED50 in group D was 0.486μg/kg (95% CI: 0.411-0.546μg/kg), while that in group C was 0.293μg/kg (95% CI: 0.252-0.336μg/kg). RD occurred in 12 patients in group D and 14 patients in group C. RD in both groups was mainly characterized by a reduced respiratory rate. There were no significant differences in the incidence or types of RD within the first 5 and 10min after administration (P > 0.05). When RD occurred, percutaneous oxygen saturation in all patients remained above 98%.
CONCLUSIONS: Dezocine can partially reverse RD induced by sufentanil and increase the ED50 of RD induced by sufentanil.