BMC ophthalmology · 2026
Comparison of early postoperative dry eye after KLEx and FS-LASIK: a contralateral eye study.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Küçüködük Ali, Aksoy Mustafa
Аннотация
OBJECTIVE: To compare early postoperative dry eye outcomes in contralateral eyes of the same patients undergoing Keratorefractive Lenticule Extraction (KLEx) versus Femtosecond Laser-Assisted Laser In Situ Keratomileusis (FS-LASIK), with tear film osmolarity defined as the primary outcome measure.
METHODS: This study was conducted at Dunyagoz Izmır Hospital and involved patients who underwent corneal refractive surgery between June 2021 and December 2024. Patients with pre-existing dry eye disease were excluded from the study. Patients underwent KLEx in one eye and FS-LASIK in the fellow eye. Tear film osmolarity (primary outcome) was measured preoperatively and postoperatively using the TearLab® system. Secondary outcome measures included tear break-up time (tBUT) and subjective symptoms assessed via the Ocular Symptom Questionnaire Scores (OSDI).
RESULTS: A total of 34 eyes of 17 patients (7 females and 10 males) were evaluated. Group 1 (KLEx) included 17 eyes and group 2 (FS-LASIK) included contralateral 17 eyes. The mean postoperative follow-up period was 34.2 days. Mean tear osmolarity was 297.7 ± 8.3 mOsm/L in the group 1 and 315.3 ± 10.2 mOsm/L in the group 2 (p < 0.001). Mean tBUT was 10.3 ± 3.1 s for group 1 and 7 ± 2.32 s for group 2 (p < 0.001). The mean postoperative OSDI scores were 32.5 for group 1 and 42 for group 2, with a preoperative baseline of 10.2 (both groups; p < 0.001).
CONCLUSIONS: KLEx demonstrated superior early postoperative ocular surface stability compared to FS-LASIK in contralateral eyes. The procedure resulted in significantly less tear hyperosmolarity and better subjective comfort, suggesting it may be a preferable surgical option for minimizing dry eye induced by corneal refractive surgery.
METHODS: This study was conducted at Dunyagoz Izmır Hospital and involved patients who underwent corneal refractive surgery between June 2021 and December 2024. Patients with pre-existing dry eye disease were excluded from the study. Patients underwent KLEx in one eye and FS-LASIK in the fellow eye. Tear film osmolarity (primary outcome) was measured preoperatively and postoperatively using the TearLab® system. Secondary outcome measures included tear break-up time (tBUT) and subjective symptoms assessed via the Ocular Symptom Questionnaire Scores (OSDI).
RESULTS: A total of 34 eyes of 17 patients (7 females and 10 males) were evaluated. Group 1 (KLEx) included 17 eyes and group 2 (FS-LASIK) included contralateral 17 eyes. The mean postoperative follow-up period was 34.2 days. Mean tear osmolarity was 297.7 ± 8.3 mOsm/L in the group 1 and 315.3 ± 10.2 mOsm/L in the group 2 (p < 0.001). Mean tBUT was 10.3 ± 3.1 s for group 1 and 7 ± 2.32 s for group 2 (p < 0.001). The mean postoperative OSDI scores were 32.5 for group 1 and 42 for group 2, with a preoperative baseline of 10.2 (both groups; p < 0.001).
CONCLUSIONS: KLEx demonstrated superior early postoperative ocular surface stability compared to FS-LASIK in contralateral eyes. The procedure resulted in significantly less tear hyperosmolarity and better subjective comfort, suggesting it may be a preferable surgical option for minimizing dry eye induced by corneal refractive surgery.