Current opinion in infectious diseases · 2025
Skin signs of invasive fungal diseases: diagnostic clues for clinicians.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fadlalla Susanne, Sprute Rosanne, Koehler Philipp, Seifert Harald, Cornely Oliver A
Аннотация
PURPOSE OF REVIEW: To emphasize the diagnostic value of cutaneous manifestations in disseminated invasive fungal disease (IFD). IFD carry high mortality and diagnosis is often delayed, while early recognition is crucial for patient outcomes. This review focuses on skin manifestations of fungi of highest relevance according to the WHO: Candida spp., Aspergillus spp., Mucorales, Fusarium spp., and Scedosporium spp.
RECENT FINDINGS: Cutaneous signs in disseminated candidiasis typically manifest as maculopapular or nodular lesions. Frequency and morphology vary depending on the Candida spp. involved. Secondary cutaneous aspergillosis presents with variable morphologies, including erythematous papules, ulcerative nodules, hemorrhagic bullae, or necrotic eschars, and may appear before standard diagnostic tests yield positive results. In invasive fusariosis, lesions typically present as vesicles or papules and progress to necrotic eschars. The morphology of skin manifestations of generalized mucormycosis varies according to the underlying disease. The formation of a necrotic eschar is considered pathognomonic. In disseminated scedosporiosis, cutaneous manifestations include ecchymoses, hemorrhagic bullae, necrotic papules, ulcers, or infiltrative plaques, often resembling infections with aspergillosis or fusariosis. Diagnosis requires a multimodal approach combining histopathology, microbiological cultures and nonculture-based assays.
SUMMARY: Despite the variability in frequency and presentation, cutaneous manifestations provide a valuable clinical clue in disseminated IFD and may facilitate early recognition and intervention.
RECENT FINDINGS: Cutaneous signs in disseminated candidiasis typically manifest as maculopapular or nodular lesions. Frequency and morphology vary depending on the Candida spp. involved. Secondary cutaneous aspergillosis presents with variable morphologies, including erythematous papules, ulcerative nodules, hemorrhagic bullae, or necrotic eschars, and may appear before standard diagnostic tests yield positive results. In invasive fusariosis, lesions typically present as vesicles or papules and progress to necrotic eschars. The morphology of skin manifestations of generalized mucormycosis varies according to the underlying disease. The formation of a necrotic eschar is considered pathognomonic. In disseminated scedosporiosis, cutaneous manifestations include ecchymoses, hemorrhagic bullae, necrotic papules, ulcers, or infiltrative plaques, often resembling infections with aspergillosis or fusariosis. Diagnosis requires a multimodal approach combining histopathology, microbiological cultures and nonculture-based assays.
SUMMARY: Despite the variability in frequency and presentation, cutaneous manifestations provide a valuable clinical clue in disseminated IFD and may facilitate early recognition and intervention.