Non-Hodgkin Lymphoma Presenting as Peritoneal Lymphomatosis: A Case Report.

Peritoneal lymphomatosis (PL) is an uncommon form of extranodal non-Hodgkin lymphoma (NHL), characterized by the spread of lymphoma cells within the peritoneum. We present a case involving a woman, age 43 years, diagnosed with diffuse large B-cell lymphoma that infiltrated the peritoneum and omentum and was accompanied by ascites and pleural effusion. Imaging revealed diffuse thickening of the peritoneum and omentum, mesenteric lymphadenopathy, and thickening of the jejunum wall. Cytology from the ascites and pleural fluid did not show malignant cells. The diagnosis was confirmed through histological and immunohistochemical analysis of tissue obtained via surgical laparoscopy. PL generally appears as an aggressive, high-grade subtype of NHL. Awareness of this rare condition is crucial for clinicians to facilitate early diagnosis and effective treatment, ultimately improving patient outcomes.