Clinical Outcomes of Hepatic Squamous Cell Carcinoma With Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation: A Case Report.

Primary squamous cell carcinoma of the liver (PSCCL) is an extremely rare disease with a poor prognosis. To date, few cancer-related genetic abnormalities in PSCCL have been reported. This report describes a case of PSCCL with FGFR2 alterations in a male patient in his 50s. The patient presented with loss of appetite and epigastric pain. Computed tomography confirmed an irregular mass in the liver and lymphadenopathy in the mediastinum and right supraclavicular region. Biopsies were obtained from the liver and right supraclavicular lymph nodes, and a diagnosis of squamous cell carcinoma was determined. No other primary lesions were identified, and PSCCL was diagnosed. Administration of gemcitabine + cisplatin and gemcitabine + S-1 was discontinued due to allergic reactions. Erdafitinib was then administered; however, the disease progressed. The patient passed away 12 months after the initial treatment. No established treatment options for PSCCL are currently available. Identifying cancer-related genetic abnormalities may help in making treatment decisions.