Dermalix enhances angiogenesis and collagen remodeling in an ischemic colon anastomosis rat model.

PURPOSE: To evaluate the effect of Dermalix on anastomotic healing in a rat model of ischemic colon anastomosis.

METHODS

Forty rats were divided into three groups: negative control (n = 10), control (n = 15), and experimental (n = 15). Only laparotomy was performed in the negative control group. In the control group, ischemia and end-to-end colon anastomosis were performed, while in the experimental group, Dermalix was applied circumferentially around the anastomosis. On postoperative day 7, anastomotic segments were evaluated for burst pressure, adhesion, and histopathological parameters.

RESULTS

Abscess formation related to anastomotic leakage occurred in two rats in the control group and in one rat in the experimental group. Mean burst pressure was 134.7 mmHg in the control group and 194.7 mmHg in the experimental group (p = 0.005). No significant differences were observed in inflammation, epithelial regeneration, or granulation tissue formation. Neovascularization (p < 0.001) and collagenization (p = 0.032) were significantly higher in the Dermalix group. There was no significant difference in adhesion or foreign body reaction.

CONCLUSION

Dermalix improved key histological and mechanical indicators of anastomotic healing under ischemic conditions, providing preliminary evidence of its potential as a bioactive adjunct. Further studies are warranted to confirm these findings and assess clinical relevance.