Cytokine · 2016
Plasma concentrations of CCL3 and CCL4 in the cardiac and digestive clinical forms of chronic Chagas disease.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Oliveira Amanda Priscila, Ayo Christiane Maria, Mimura Kallyne Kioko Oliveira, Oliani Sonia Maria, Bernardo Cássia Rubia, Camargo Ana Vitória Silveira, Ronchi Luís Sérgio, Borim Aldenis Albaneze, de Campos Júnior Eumildo, Brandão de Mattos Cinara Cássia, Castiglioni Lilian, Bestetti Reinaldo Bulgarelli, Cavasini Carlos Eugênio, de Mattos Luiz Carlos
Аннотация
The aim of this study was to investigate the plasma levels of the CCL3 and CCL4 chemokines in patients with the cardiac and digestive clinical forms of chronic Chagas disease and in cardiac patients with and without left ventricular systolic dysfunction (LVSD). Plasma samples from 75 patients were evaluated by enzyme-linked immunosorbent assay (ELISA) to confirm infection by T. cruzi. Plasma levels of the CCL3 and CCL4 chemokines were measured using Milliplex® MAP assay (Millipore). There were no significant differences in the levels of CCL3 and CCL4 between patients with the digestive and cardiac clinical forms of Chagas disease. Moreover, no significant differences were found between patients without LVSD and those with LVSD. Higher CCL3 and CCL4 plasma levels were found in patients with LVSD compared to those with the digestive form of the disease. The CCL3 and CCL4 chemokines might not be involved in differential susceptibility to the digestive and cardiac clinical forms of chronic Chagas disease, and it seems they do not influence the development of LVSD.