Modern rheumatology · 2025
A study of clinical features of atrophic gastritis in patients with Sjögren's disease.
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Nishiyama Susumu, Ohashi Keiji, Aita Tetsushi, Yoshinaga Yasuhiko
Аннотация
OBJECTIVES: Patients with Sjogren's disease (SjD) are known to develop atrophic gastritis. Our aim is to examine the prevalence rate of atrophic gastritis in patients with SjD and its association with Helicobacter pylori infection and autoantibodies.
METHODS: We collected data of 103 patients with SjD, who underwent upper endoscopy at our hospital from January 2004 to June 2024. Helicobacter pylori infection was determined by at least one of the following methods, the urease test, the 13C-urea breath test, and the blood test for H. pylori antibody.
RESULTS: The prevalence rate of atrophic gastritis in patients with SjD was 68.0%. Around half of the patients (56.1%) with atrophic gastritis were positive for H. pylori tests. Primary SjD patients with atrophic gastritis had significantly higher positive rates of anti-La/SSB antibody than those with other gastric findings (38.5% vs. 5.9%, P < .05). There was no difference in anti-La/SSB antibody prevalence between H. pylori positive and negative group.
CONCLUSION: Anti-La/SSB antibody, other than H. pylori may contribute to develop atrophic gastritis in patients with primary SjD.
METHODS: We collected data of 103 patients with SjD, who underwent upper endoscopy at our hospital from January 2004 to June 2024. Helicobacter pylori infection was determined by at least one of the following methods, the urease test, the 13C-urea breath test, and the blood test for H. pylori antibody.
RESULTS: The prevalence rate of atrophic gastritis in patients with SjD was 68.0%. Around half of the patients (56.1%) with atrophic gastritis were positive for H. pylori tests. Primary SjD patients with atrophic gastritis had significantly higher positive rates of anti-La/SSB antibody than those with other gastric findings (38.5% vs. 5.9%, P < .05). There was no difference in anti-La/SSB antibody prevalence between H. pylori positive and negative group.
CONCLUSION: Anti-La/SSB antibody, other than H. pylori may contribute to develop atrophic gastritis in patients with primary SjD.