Acta neurologica Taiwanica · 2026
Taiwan Poststroke Disability Study: A Study Protocol.
Протокол клинического исследованияСтатьяНазвание и аннотация: Перевод в очереди
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Chen Chih-Hao, Tsai Li-Kai, Chang Ting-Yu, Su Hui-Chen, Sung Pi-Shan, Chou Chung-Hsing, Tung Hsin, Hsieh Yi-Chen, Chung Chih-Ping, Chan Lung, Chiou Hung-Yi, Lien Li-Ming, Jeng Jiann-Shing
Аннотация
BACKGROUND: Stroke is a leading cause of mortality and disability in Taiwan, necessitating a comprehensive understanding of its long-term impacts.
OBJECTIVES: This study aims to investigate the prevalence, risk factors, and progression of poststroke disabilities across motor, swallowing, cognitive, emotional, epilepsy, and quality-of-life domains.
MATERIALS AND METHODS: This multicenter, prospective cohort study will recruit 2000 acute ischemic and hemorrhagic stroke patients from 14 major hospitals in Taiwan. Assessments will be conducted at baseline, 3 months, and 12 months poststroke using validated tools, questionnaires, imaging, and blood biomarkers (ClinicalTrials registered no: NCT06772194).
RESULTS: Key outcomes include motor function recovery, prevalence of dysphagia, cognitive impairment, poststroke depression, and epilepsy, as well as quality-of-life measures. Advanced imaging techniques and biomarker analyses, including genome-wide association studies, will explore predictors of disability and recovery.
CONCLUSIONS: This study seeks to address gaps in stroke recovery research by integrating clinical and biological data to enhance personalized stroke management. T-PODS is expected to inform strategies for reducing disability and improving long-term outcomes for stroke survivors in Taiwan, contributing to the global effort to optimize stroke care and rehabilitation.
OBJECTIVES: This study aims to investigate the prevalence, risk factors, and progression of poststroke disabilities across motor, swallowing, cognitive, emotional, epilepsy, and quality-of-life domains.
MATERIALS AND METHODS: This multicenter, prospective cohort study will recruit 2000 acute ischemic and hemorrhagic stroke patients from 14 major hospitals in Taiwan. Assessments will be conducted at baseline, 3 months, and 12 months poststroke using validated tools, questionnaires, imaging, and blood biomarkers (ClinicalTrials registered no: NCT06772194).
RESULTS: Key outcomes include motor function recovery, prevalence of dysphagia, cognitive impairment, poststroke depression, and epilepsy, as well as quality-of-life measures. Advanced imaging techniques and biomarker analyses, including genome-wide association studies, will explore predictors of disability and recovery.
CONCLUSIONS: This study seeks to address gaps in stroke recovery research by integrating clinical and biological data to enhance personalized stroke management. T-PODS is expected to inform strategies for reducing disability and improving long-term outcomes for stroke survivors in Taiwan, contributing to the global effort to optimize stroke care and rehabilitation.