Viruses · 2023
Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Menezes Mariane Talon, Moreira Filipe Romero Rebello, Whittaker Charles, Santos Franciele Martins, Queiroz Daniel Costa, Geddes Victor, Fonseca Paula Luize Camargos, de Jesus Jaqueline Góes, Mendes-Oliveira Franciane, Reis-Souza Valquíria, Santos Bibiana, Zauli Danielle Alves Gomes, de Lima Aline Brito, de Brito Mendonça Cristiane, Alvim Luige Biciati, do Prado Silva Joice, Malta Frederico Scott Varella, de Souza Ferreira Alessandro Clayton, Faria Nuno R, Sabino Ester Cerdeira, Aguiar Renato Santana
Аннотация
Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.