Journal of biomedical science · 2013
Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells.
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Liu Jing, Yang Shaobo, Wang Zhiqiang, Chen Xiao, Zhang Ziqi
Аннотация
BACKGROUND: Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating the activities of epithelial cells. This study was designed to investigate the role of the colon polyp epithelium-derived A20 in the pathogenesis of colon cancer.
RESULTS: Eighty-eight colon cancer patients and 136 colon polyp patients were recruited into this study. Human colon cancer tissue, the epithelium of adenomas polyp and hyperplastic polyp showed high levels of A20, which had a positive correlation with the cancerous tendency of colon polyps. The levels of A20 were much higher in the adenomas and hyperplastic polyps than that in the inflammatory polyps; the latter showed less cancerous tendency. A20 bound p53 to form complexes in colon cancer tissue and colon polyps. Over expression of A20 suppresses P53 protein levels in the HEK293 cells.
CONCLUSIONS: A20 may play an important role in the cancerous tendency of colon polyposis.
RESULTS: Eighty-eight colon cancer patients and 136 colon polyp patients were recruited into this study. Human colon cancer tissue, the epithelium of adenomas polyp and hyperplastic polyp showed high levels of A20, which had a positive correlation with the cancerous tendency of colon polyps. The levels of A20 were much higher in the adenomas and hyperplastic polyps than that in the inflammatory polyps; the latter showed less cancerous tendency. A20 bound p53 to form complexes in colon cancer tissue and colon polyps. Over expression of A20 suppresses P53 protein levels in the HEK293 cells.
CONCLUSIONS: A20 may play an important role in the cancerous tendency of colon polyposis.
Предметные рубрики MeSH
AdenomaAdultAgedBlotting, WesternCarcinogenesisColonColonic PolypsDNA-Binding ProteinsEnzyme-Linked Immunosorbent AssayEpithelial CellsFemaleGene Expression Regulation, NeoplasticHEK293 CellsHumansHyperplasiaIntracellular Signaling Peptides and ProteinsMaleMiddle AgedNuclear ProteinsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor alpha-Induced Protein 3Tumor Suppressor Protein p53