Frontiers in immunology · 2026
Clinical and electrodiagnostic features of nerve conduction study-classified peripheral neuropathy in symptomatic patients with antineutrophil cytoplasmic antibody-associated vasculitis: a single-centre cohort study.
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Ha Jang Woo, Kwon Oh Chan, Park Yong-Beom, Lee Sang-Won
Аннотация
BACKGROUND: This study investigated the clinical and electrodiagnostic features of vasculitic peripheral neuropathy (VPN) in symptomatic patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) who underwent nerve conduction studies (NCS) within 3 months after AAV diagnosis.
METHODS: Among 323 patients with AAV, 97 presenting with clinical symptoms suggestive of VPN and with the availability of results of NCS performed within 3 months after AAV diagnosis were included in this study. VPN was classified based on the case definition and guidelines proposed by the Brighton Collaboration Vasculitic Peripheral Neuropathy Working Group in 2017. Of the 97 patients, 12 underwent nerve biopsy.
RESULTS: At AAV diagnosis, the median age of the 97 patients was 63.0 years (57% women), consisting of 48 patients with microscopic polyangiitis (MPA), 20 with granulomatosis with polyangiitis (GPA), and 29 with eosinophilic granulomatosis with polyangiitis (EGPA). Among symptomatic AAV patients who underwent early NCS, 55 patients (56.7%) were classified as having electrodiagnostically supported VPN. The most common type of VPN was a mixed type (83.6%), and the most frequently affected nerve was the peroneal nerve (70.9%). The concordance rate between NCS and nerve biopsy findings was 75% based on histological evidence of vasculitis.
CONCLUSION: In this selected cohort of symptomatic AAV patients who underwent NCS within 3 months after diagnosis, more than half were classified as having electrodiagnostically supported VPN. NCS may provide adjunctive objective information for characterizing peripheral nerve involvement in clinically suspected VPN.
METHODS: Among 323 patients with AAV, 97 presenting with clinical symptoms suggestive of VPN and with the availability of results of NCS performed within 3 months after AAV diagnosis were included in this study. VPN was classified based on the case definition and guidelines proposed by the Brighton Collaboration Vasculitic Peripheral Neuropathy Working Group in 2017. Of the 97 patients, 12 underwent nerve biopsy.
RESULTS: At AAV diagnosis, the median age of the 97 patients was 63.0 years (57% women), consisting of 48 patients with microscopic polyangiitis (MPA), 20 with granulomatosis with polyangiitis (GPA), and 29 with eosinophilic granulomatosis with polyangiitis (EGPA). Among symptomatic AAV patients who underwent early NCS, 55 patients (56.7%) were classified as having electrodiagnostically supported VPN. The most common type of VPN was a mixed type (83.6%), and the most frequently affected nerve was the peroneal nerve (70.9%). The concordance rate between NCS and nerve biopsy findings was 75% based on histological evidence of vasculitis.
CONCLUSION: In this selected cohort of symptomatic AAV patients who underwent NCS within 3 months after diagnosis, more than half were classified as having electrodiagnostically supported VPN. NCS may provide adjunctive objective information for characterizing peripheral nerve involvement in clinically suspected VPN.