Preoperative parathyroid hormone level as a predictor of parathyroid adenoma size in surgically treated patients with primary hyperparathyroidism.

INTRODUCTION

Primary hyperparathyroidism (PHPT) is most commonly caused by a solitary parathyroid adenoma. The relationship between parathyroid hormone (PTH) lev-els and adenoma size remains unclear.

METHODS

A retrospective analysis of 377 PHPT patients who underwent surgery at Third Department of Surgery, First Faculty of Medicine, Charles University and Motol University Hospital (2022-2023). Adenoma volume was calculated as an ellipsoid. The cor-relation between PTH and adenoma volume was assessed using regression analysis.

RESULTS

A weak to moderate correlation was found (R = 0.315; P < 0.001). Linear regres-sion showed that a 1 pmol/L increase in PTH corresponded to an average adenoma volume increase of 104 mm³.

CONCLUSION

Preoperative PTH levels partially correlate with adenoma volume, but their predictive value is limited.