Journal of perinatology : official journal of the California Perinatal Association · 2025
Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.
СтатьяНазвание и аннотация: Перевод в очереди
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Di Fiore Juliann M, Chen Zhengyi, Minich Nori, Wilson-Costello Deanne, Martin Richard J, Hibbs Anna Maria
Аннотация
BACKGROUND: Intermittent hypoxemia events (IH) in preterm infants may alter airway function manifesting as childhood wheezing.
OBJECTIVE: Characterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age.
STUDY DESIGN: IH < 80% and <90% and number of wheezing episodes were documented in infants <31 weeks gestation discharged prior to and during COVID-19 social isolation.
RESULTS: A greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH < 80 and 90%, all p < 0.05) and through 24 months in infants <28wks GA discharged during COVID-19 isolation (IRRs, 1.03-1.25, IH < 80 and 90%, all p < 0.05).
CONCLUSION: Associations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.
OBJECTIVE: Characterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age.
STUDY DESIGN: IH < 80% and <90% and number of wheezing episodes were documented in infants <31 weeks gestation discharged prior to and during COVID-19 social isolation.
RESULTS: A greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH < 80 and 90%, all p < 0.05) and through 24 months in infants <28wks GA discharged during COVID-19 isolation (IRRs, 1.03-1.25, IH < 80 and 90%, all p < 0.05).
CONCLUSION: Associations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.