Frontiers in oncology · 2026
Granulomatous cutaneous T-cell lymphoma in a patient with atage IVB of mycosis fungoides: a case report and literature review.
СтатьяНазвание и аннотация: Перевод в очереди
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Lin Zhu, Xue Jing, Ye Guozeng, Li Shuang, Liu Tingzhi, Lang Jiping, Zheng Zhixin, Li Xiaoyan, Wang Qinbo, Chen Junrong
Аннотация
BACKGROUND: Granulomatous mycosis fungoides (GMF) represents a distinct pathological variant of mycosis fungoides (MF), mycosis fungoides, originating from memory helper T cells, is the most prevalent form of primary cutaneous T-cell lymphoma. It is characterized as an inactive CD4+ non-Hodgkin lymphoma, where in some patients lesions gradually evolve into plaques or tumors over several years.
PRESENTATION: The patient presented with multiple masses on his trunk and limbs, featuring ulcers and scab formation, the patient was previously diagnosed with "psoriasis" before, however, clinicopathological correlation led to a diagnosis of granulomatous mycosis fungoides (GMF). The clinical and histological presentations of GMF are heterogeneous, and often mimic those of various inflammatory skin disorders. The patient's erythema and mass were biopsied separately, and the tumor cell characteristics included positivity for CD3+ and negativity for CD7-, CD4-, and CD8-. Immunohistochemical evaluations showed diffuse positivity for both T-cell lineage markers (CD2 and CD3), EBV in situ hybridization showed EBER (-). Absence noted surrounding (CD56), indicating active hyperplastic states existing within the bone marrow composition. TCRβ and γ genes detection confirmed the presence of a clonal process.
CONCLUSION: This report explores the clinical and histological manifestations of GMF, features distinguishing GMF from other granulomatous diseases, such as IGD, and the prognostic significance of distinguishing GMF from classic mycosis fungoides. We aimed to raise awareness among physicians regarding this rare disease and emphasize the characteristic histological features of GMF that can be confused with other types of mycosis fungoides.
PRESENTATION: The patient presented with multiple masses on his trunk and limbs, featuring ulcers and scab formation, the patient was previously diagnosed with "psoriasis" before, however, clinicopathological correlation led to a diagnosis of granulomatous mycosis fungoides (GMF). The clinical and histological presentations of GMF are heterogeneous, and often mimic those of various inflammatory skin disorders. The patient's erythema and mass were biopsied separately, and the tumor cell characteristics included positivity for CD3+ and negativity for CD7-, CD4-, and CD8-. Immunohistochemical evaluations showed diffuse positivity for both T-cell lineage markers (CD2 and CD3), EBV in situ hybridization showed EBER (-). Absence noted surrounding (CD56), indicating active hyperplastic states existing within the bone marrow composition. TCRβ and γ genes detection confirmed the presence of a clonal process.
CONCLUSION: This report explores the clinical and histological manifestations of GMF, features distinguishing GMF from other granulomatous diseases, such as IGD, and the prognostic significance of distinguishing GMF from classic mycosis fungoides. We aimed to raise awareness among physicians regarding this rare disease and emphasize the characteristic histological features of GMF that can be confused with other types of mycosis fungoides.