Revista da Sociedade Brasileira de Medicina Tropical · 2019
Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats.
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Loth Eduardo Alexandre, Cecatto Vanessa, Genske Rodrigo Daniel, Costa Maricília Silva, Gandra Rinaldo Ferreira, Pilatti Cleverson Marcelo
Аннотация
INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.
METHODS: Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.
RESULTS: Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.
CONCLUSIONS: Articular arthritic lesions were induced and progressed during the study period in all experimental groups.
METHODS: Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.
RESULTS: Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.
CONCLUSIONS: Articular arthritic lesions were induced and progressed during the study period in all experimental groups.