Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats.

INTRODUCTION

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.

METHODS

Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.

RESULTS

Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.

CONCLUSIONS

Articular arthritic lesions were induced and progressed during the study period in all experimental groups.