Biomarkers in medicine · 2025
Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.
СтатьяНазвание и аннотация: Перевод в очереди
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Mołek-Dziadosz Patrycja, Natorska Joanna, Matusik Paweł T, Wojciechowska Wiktoria, Rajzer Marek, Rajtar-Salwa Renata, Bartuś Stanisław, Surdacki Andrzej, Malinowski Krzysztof P, Lenart-Migdalska Aleksandra, Olszowska Maria, Ząbczyk Michał
Аннотация
BACKGROUND: Atrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.
MATERIALS AND METHODS: In 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.
RESULTS: AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.
CONCLUSIONS: Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.
MATERIALS AND METHODS: In 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.
RESULTS: AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.
CONCLUSIONS: Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.