Curcumin-based Nanotherapeutics to Combat Neurodegenerative Disease: Drug Delivery Strategies and Therapeutic Potential.

Curcumin (CUR) has been used as a medicine, colouring agent, and flavouring agent for thousands of years. Polyphenolic active constituents of turmeric show antimicrobial, anticancer, antioxidant, anti-inflammatory, astringent, and other valuable properties. Numerous studies on animals have demonstrated that CUR is safe, with no harmful effects on the kidney and liver, even at higher doses. This review article aims to gather information about the properties and the use of active constituents of CUR in nanotechnology-based treatment strategies for neurodegenerative diseases (NDs). From scientific articles published in different scientific platforms, including PubMed, Scopus, Web of Science, and Google Scholar, potentially relevant literature was compiled to update on CUR and innovative nanocarrier-based approaches for the treatment of NDs. The primary issue is the low solubility of CUR, so various nanocarriers with biocompatible, non-toxic, cost-effective, and biodegradable properties are used today to increase solubility, enhance penetration rate, reduce dose recurrence, and improve efficacy. It is believed that the phenolic compounds found in turmeric have a neuroprotective effect. Based on numerous pharmacological practices, CUR has been identified as an ideal candidate for various neurological disorders. It can cross the blood-brain barrier (BBB), exhibiting remarkable anti-inflammatory and neuroprotective effects. Use of CUR with nanocarriers can be a potent therapeutic option for NDs.