Tectal gliomas with "low-grade appearance": Natural history on MR imaging.

BACKGROUND

Tectal gliomas (TGs) are often indolent, but heterogeneous study populations in prior cohorts yielded ambiguous results concerning their natural history. We analyzed the natural history of TGs with low-grade appearance on MR imaging.

METHODS

We retrospectively analyzed TGs treated at our institution between 2010 and 2023. We included any space-occupying lesion of the tectum, excluding lesions with nodular contrast enhancement, cystic changes, or primarily pontine or mesencephalic involvement. Volumetric analysis was exclusively based on thin-sliced MRI sequences (≤2 mm). The primary outcome was tumor growth. The secondary outcome was relative annual growth rate (RGR).

RESULTS

Twenty patients met the inclusion criteria (median age 22.5 years, interquartile range [IQR] 18.7-39.6). Headache was the most common indication for imaging (60%). Twelve patients (60%) required cerebrospinal fluid (CSF) diversion for hydrocephalus at the time of diagnosis. These patients did not all present with headaches upon first consultation. Median follow-up was 6.3 years (IQR 2.2-9.8). Median volumetric change from baseline to last follow-up was +3.25% (IQR -10.53 to +28.47%), with a median RGR of 0.87%/year (IQR -1.28 to 11.05%/year). Only 1 patient exhibited tumor growth with a marginal increase in size over 12.8 years of follow-up. Based on MR imaging findings, no malignant transformation occurred in our cohort.

CONCLUSIONS

TG with a low-grade imaging phenotype shows a predominantly stable long-term course. Management is typically limited to CSF diversion for hydrocephalus. Routine tumor-directed therapy is not supported in the absence of concerning clinical or imaging features. Magnetic resonance imaging surveillance remains essential to detect rare progression.