Head and neck pathology · 2026
Extensive Bone Destruction, Lymphovascular and Perineural Invasion, and Local Recurrence: Unusual Features in Salivary Gland Microsecretory Adenocarcinoma.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Kakkar Aanchal, Mahendru Ria, Singh Pavit, Saifi Sheeba, Sivadas Shijitha, Gautam Vimmi, Justine Deepak, Kaur Kavneet, Manchanda Smita, Bhalla Ashu Seith, Kumar Rajeev, Singh Chirom Amit, Sikka Kapil
Аннотация
PURPOSE: Microsecretory adenocarcinoma (MSA) is a recently described salivary gland adenocarcinoma with distinctive histological features and novel genetic signature viz. MEF2C::SS18 fusion. Archival diagnoses are most frequently adenocarcinoma, not otherwise specified (NOS) and polymorphous adenocarcinoma (PAC). To date, most documented MSA cases have shown indolent behaviour, supporting their categorization as low-grade adenocarcinomas.
METHODS: Molecularly confirmed cases of MSA with unusual clinical and histological features indicative of aggressiveness are described. Archival cases of adenocarcinoma NOS and PAC were assessed to identify potential MSA cases.
RESULTS: Three MSA cases showed features of aggressiveness: large size, extensive bone destruction and lymphovascular invasion in one case; perineural invasion in two cases; and predominance of solid architecture and local recurrence in one case. One patient died of unrelated causes; the other two are disease-free at 40 and 31 months, respectively. Review of six adenocarcinoma NOS and 14 PAC did not yield any potential cases of MSA. FISH for SS18 rearrangement was negative in all adenocarcinoma NOS.
CONCLUSIONS: Bland cytomorphological features typical of fusion-associated neoplasms do not preclude presence of aggressive histological features and development of recurrence in MSA. These aggressive features may serve as indicators for escalation of treatment, despite the low-grade appearance of MSA.
METHODS: Molecularly confirmed cases of MSA with unusual clinical and histological features indicative of aggressiveness are described. Archival cases of adenocarcinoma NOS and PAC were assessed to identify potential MSA cases.
RESULTS: Three MSA cases showed features of aggressiveness: large size, extensive bone destruction and lymphovascular invasion in one case; perineural invasion in two cases; and predominance of solid architecture and local recurrence in one case. One patient died of unrelated causes; the other two are disease-free at 40 and 31 months, respectively. Review of six adenocarcinoma NOS and 14 PAC did not yield any potential cases of MSA. FISH for SS18 rearrangement was negative in all adenocarcinoma NOS.
CONCLUSIONS: Bland cytomorphological features typical of fusion-associated neoplasms do not preclude presence of aggressive histological features and development of recurrence in MSA. These aggressive features may serve as indicators for escalation of treatment, despite the low-grade appearance of MSA.