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Nature genetics · 2026

Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.

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Streit Fabian, Awasthi Swapnil, Hall Alisha S M, Braun Alice, Niarchou Maria, Marouli Eirini, Babajide Oladapo, Frank Josef, Zillich Lea, Callies Carolin M, Avetyan Diana, Zillich Eric, Naamanka Joonas, Gonzalez Jean, Harder Arvid, Lu Yi, Aherrahrou Zouhair, Ahmad Zain-Ul-Abideen, Ask Helga, Batzler Anthony, Benros Michael E, Brand-de Wilde Odette M, Brunak Søren, Bruun Mie T, Christoffersen Lea A N, Colodro-Conde Lucía, Coombes Brandon J, Corfield Elizabeth C, Dahmen Norbert, Didriksen Maria, Dinh Khoa M, Djurovic Srdjan, Dowsett Joseph, Drange Ole Kristian, Dukal Helene, Edelmann Susanne, Erikstrup Christian, Espinola Mariana K, Fassbinder Eva, Faucon Annika, Ferreira de Sá Diana S, Foo Jerome C, Gilles Maria, Gutiérrez-Zotes Alfonso, Hansen Thomas F, Haraldsson Magnus, Harper R Patrick, Havdahl Alexandra, Heilbronner Urs, Herms Stefan, Hjalgrim Henrik, Hübel Christopher, Jacob Gitta A, Aagaard Bitten, Jorgensen Anders, Jungkunz Martin, Kleindienst Nikolaus, Knoblich Nora, Koglin Stefanie, Kraft Julia, Krebs Kristi, Lee Christopher W, Lin Yuhao, Lis Stefanie, Lisoway Amanda, Malogiannis Ioannis A, Martinsen Amy, Maslahati Tolou, Merz Katharina, Meyer-Lindenberg Andreas, Mikkelsen Susan, Mikkelsen Christina, Mobascher Arian, Muntané Gerard, Oddsson Asmundur, Ostrowski Sisse R, Palviainen Teemu, Pedersen Ole B V, Pedersen Geir, Quinn Liam, Reinhard Matthias A, Ruths Florian A, Schott Björn H, Schredl Michael, Schwarz Emanuel, Schwarze Cornelia E, Schwinn Michael, Send Tabea Sarah, Sigurdsson Engilbert, Simon-Keller Katja, Skuladottir Astros T, Soler Joaquim, Sonley Anne, Sørensen Erik, Stefansson Hreinn, Straub Peter, Suvisaari Jaana, Tesli Martin, Træholt Jacob, Ullum Henrik, Völker Maja P, Walters G Bragi, Wang Rujia, Witt Christian C, Zarbock Gerhard, Zill Peter, Zwart John-Anker, DBDS Genomic Consortium, GLAD Study, HUNT All-In Psychiatry, Andreassen Ole A, Arntz Arnoud, Biernacka Joanna M, Bohus Martin, Breen Gerome, Chapman Alexander L, Cichon Sven, Davis Lea K, Deuschle Michael, Euler Sebastian, Herpertz Sabine C, Hummelen Benjamin, Jobst Andrea, Kaprio Jaakko, Kennedy James L, Lehto Kelli, Lieb Klaus, Martorell Lourdes, McMain Shelley, Musil Richard, Nieratschker Vanessa, Nöthen Markus M, Padberg Frank, Palotie Aarno, Pascual Juan C, Perroud Nader, Ramos-Quiroga Josep A, Reichborn-Kjennerud Ted, Ribases Marta, Roepke Stefan, Rujescu Dan, Sanchez-Roige Sandra, Schilling Claudia, Schmahl Christian, Stefansson Kari, Thorgeirsson Thorgeir E, Turecki Gustavo, Vilella Elisabet, Werge Thomas, Winsvold Bendik S, Wrege Johannes, Rietschel Marcella, Ripke Stephan, Witt Stephanie H

Аннотация

Borderline personality disorder (BPD) is a severe mental health condition influenced by environmental risk factors (for example, interpersonal trauma) and genetic factors. We conducted the largest genome-wide association study (GWAS) meta-analysis of BPD so far, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participants of European ancestry). We identified 11 independent associated genomic loci and 9 risk genes in gene-based analyses. We observed a single-nucleotide polymorphism heritability of 17.3% and derived polygenic scores (PGS) that predicted 4.6% of the phenotypic variance in BPD on the liability scale. BPD showed the strongest positive genetic correlations with GWAS of post-traumatic stress disorder, depression, attention deficit hyperactivity disorder, antisocial behavior, and measures of suicide and self-harm. Phenome-wide analyses in Vanderbilt University Medical Center Biobank and UK Biobank using BPD-PGS confirmed these associations and also identified associations with other medical conditions, including obstructive pulmonary disease and diabetes. These analyses highlight BPD as a polygenic disorder, with the genetic risk showing substantial overlap with psychiatric and physical health conditions.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты