Heart & lung : the journal of critical care · 2026
Outcomes of critically ill patients with obesity hypoventilation syndrome presenting with acute hypercapnic respiratory failure.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Álvarez-Maldonado Pablo, Hernández-Ríos Grisel, Hernández-Solís Alejandro, Reding-Bernal Arturo, Espinosa-Ramírez José Guillermo, Navarro-Reynoso Francisco
Аннотация
BACKGROUND: Acute-on-chronic hypercapnic respiratory failure (AHRF) is among the most common causes of hospitalization in patients with obesity hypoventilation syndrome (OHS), and is associated with high mortality rates OBJECTIVES: To characterize the clinical features and identify mortality risk factors in patients with confirmed or suspected OHS admitted to the ICU for AHRF.
METHODS: Retrospective analysis of patients admitted to the respiratory-ICU of a tertiary academic hospital. Data was extracted from a prospective database covering from January 2010 to June 2025. Bivariate analyses and multivariable logistic regression were used to identify factors independently associated with in-hospital mortality.
RESULTS: Among 5025 ICU admissions, 333 patients met inclusion criteria: 266 (79.8 %) with confirmed OHS and 67 (20.2 %) classified as suspected OHS. The mean age was 50.6±14.0 years; 56.5 % were male. Overall mortality was 48 % (n=160). Noninvasive mechanical ventilation prevented intubation in 44 % of subjects. In bivariate analysis, age, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score-3 (SAPS-3), and hypertension were associated with increased mortality. Multivariable regression identified age (OR 1.02 per year; p=0.039) and SOFA (OR 1.69 per point; p<0.001) as independent predictors of mortality. Conversely, tracheostomy was associated with a lower risk of death (OR 0.26; p=0.007).
CONCLUSIONS: OHS-related AHRF is a common cause of ICU admission in obese patients and is associated with high mortality. Age and SOFA score are independent predictors of poor outcomes, while tracheostomy appears to confer a survival benefit. These findings highlight the need for early identification and tailored management in this understudied population.
METHODS: Retrospective analysis of patients admitted to the respiratory-ICU of a tertiary academic hospital. Data was extracted from a prospective database covering from January 2010 to June 2025. Bivariate analyses and multivariable logistic regression were used to identify factors independently associated with in-hospital mortality.
RESULTS: Among 5025 ICU admissions, 333 patients met inclusion criteria: 266 (79.8 %) with confirmed OHS and 67 (20.2 %) classified as suspected OHS. The mean age was 50.6±14.0 years; 56.5 % were male. Overall mortality was 48 % (n=160). Noninvasive mechanical ventilation prevented intubation in 44 % of subjects. In bivariate analysis, age, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score-3 (SAPS-3), and hypertension were associated with increased mortality. Multivariable regression identified age (OR 1.02 per year; p=0.039) and SOFA (OR 1.69 per point; p<0.001) as independent predictors of mortality. Conversely, tracheostomy was associated with a lower risk of death (OR 0.26; p=0.007).
CONCLUSIONS: OHS-related AHRF is a common cause of ICU admission in obese patients and is associated with high mortality. Age and SOFA score are independent predictors of poor outcomes, while tracheostomy appears to confer a survival benefit. These findings highlight the need for early identification and tailored management in this understudied population.