Journal of assisted reproduction and genetics · 2021
Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Le Ho Long, Ho Vu Ngoc Anh, Le Tam Thi Ngan, Tran Van Thi Thu, Ma Mai Pham Que, Le Anh Hoang, Nguyen Linh Khanh, Ho Tuong Manh, Vuong Lan Ngoc
Аннотация
PURPOSE: Gonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM).
METHODS: Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.
RESULTS: Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.
CONCLUSIONS: These results suggest that IVM should be a first-line therapeutic option for patients with GROS.
METHODS: Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.
RESULTS: Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.
CONCLUSIONS: These results suggest that IVM should be a first-line therapeutic option for patients with GROS.