[Pathology analysis of CD31,CD34 and vWF expression in vascular endothelial cell of granulation tissue of eyelid chalazion].

PURPOSE: To investigate the variable expressions of CD31, CD34, vWF during the vascular development process of growing granulation tissue of eyelid chalazion.

METHODS

The samples of growing granulation tissue were obtained during chalazion removal surgery. Immunohistochemistry staining technique was used to detect the expression of CD31, CD34 and vWF in vascular endothelial cells.

RESULTS

CD31 and CD34 were expressed in all vascular endothelial cells, whereas the CD34 was more effectively expressed and strengthened in the capillary sprouts. The vWF was not expressed in capillary sprouts, but the expression was stronger in the tissues from superficial to deeper layers.

CONCLUSIONS

CD31, CD34 and vWF expression in microvascular endothelial cells of growing granulation tissue is diversified. CD34 may be an import marker for active angiogenesis and vWF is an effective marker for inactive angiogenesis.