Cell adhesion & migration · 2010
Eph-ephrin bidirectional signaling comes into the context of lymphocyte transendothelial migration.
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Liu Bethina, Orakwue Chimsom, Ryan Kara, Manolas Melina I, Kumar Sonal
Аннотация
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent, yet underrecognized condition with serious, but preventable, complications. The American Association for the Study of Liver Diseases, American Association of Clinical Endocrinology (2022), and American Diabetes Association (2025) recommend MASLD screening for patients with type 2 diabetes, including using the Fibrosis-4 (FIB-4) index for noninvasive risk stratification of those needing further evaluation. Primary care physicians are key to early diagnosis but may be unfamiliar with updated guidelines.
METHODS: A 30-minute case-based educational session on MASLD was delivered to 54 internal medicine residents in small groups during 2023-2024. Sessions integrated retrieval-based learning, brief didactics, and facilitated discussion. Participants completed 3 surveys (presession, immediately postsession, and year's end) assessing MASLD knowledge and perceived clinical impact. Scores (correct answer = 1 point, 12 total) overall and by category (Epidemiology, Practices) were analyzed by ANOVA and paired t tests.
RESULTS: Among 47 survey 1 respondents, 41 survey 2 respondents, and 9 survey 3 respondents, respective mean scores were 6.57, 9.20, and 8.00 overall (p < .001); 1.91, 3.88, and 2.56 for Epidemiology (p < .001); and 4.66, 5.32, and 5.44 for Practices (p = .006). Mean scores increased on survey 2 (overall +2.59; Epidemiology +1.95; Practices +0.63; each p < .001). Survey 3 mean scores increased for Practices (+1.22, p = .01), with 71% reporting screening changes and 76% reporting referral practice changes.
DISCUSSION: Targeted interventions improved knowledge of guideline-based MASLD screening, FIB-4 interpretation, and indications for hepatology referral.
METHODS: A 30-minute case-based educational session on MASLD was delivered to 54 internal medicine residents in small groups during 2023-2024. Sessions integrated retrieval-based learning, brief didactics, and facilitated discussion. Participants completed 3 surveys (presession, immediately postsession, and year's end) assessing MASLD knowledge and perceived clinical impact. Scores (correct answer = 1 point, 12 total) overall and by category (Epidemiology, Practices) were analyzed by ANOVA and paired t tests.
RESULTS: Among 47 survey 1 respondents, 41 survey 2 respondents, and 9 survey 3 respondents, respective mean scores were 6.57, 9.20, and 8.00 overall (p < .001); 1.91, 3.88, and 2.56 for Epidemiology (p < .001); and 4.66, 5.32, and 5.44 for Practices (p = .006). Mean scores increased on survey 2 (overall +2.59; Epidemiology +1.95; Practices +0.63; each p < .001). Survey 3 mean scores increased for Practices (+1.22, p = .01), with 71% reporting screening changes and 76% reporting referral practice changes.
DISCUSSION: Targeted interventions improved knowledge of guideline-based MASLD screening, FIB-4 interpretation, and indications for hepatology referral.