Neuroradiology · 2025
Magnetic resonance imaging morphological features of the cisternal segment of the trigeminal nerve in Fabry disease.
СтатьяНазвание и аннотация: Перевод в очереди
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Gomi Taku, Matsushima Satoshi, Baba Akira, Tsunogai Toshiki, Shimizu Tetsuya, Kuribayashi Hideto, Nishida Hikaru, Sakurai Ken, Kobayashi Masahisa, Kobayashi Hiroshi, Ojiri Hiroya
Аннотация
PURPOSE: To investigate the magnetic resonance imaging (MRI) characteristics of the trigeminal nerve in Fabry disease (FD) by comparing the morphology of the trigeminal nerve in patients with and without FD.
METHODS: This retrospective study included 40 patients with FD and 40 age- and sex-matched controls who underwent 3T MRI with constructive interference in steady-state sequence. Two neuroradiologists measured the short-axis length on axial and oblique coronal images and the long-axis length and cross-sectional area on oblique coronal images of the cisternal segment of the trigeminal nerve bilaterally. Morphological differences were assessed between groups and between sides within each group using appropriate t-tests.
RESULTS: All measurements were significantly smaller in the FD group than in the control group: axial images: short-axis length (3.20 ± 0.52 mm vs. 3.51 ± 0.51 mm, p = 0.0101); oblique coronal images: short-axis length (2.41 ± 0.28 mm vs. 2.61 ± 0.35 mm, p = 0.007); long-axis length (3.75 ± 0.53 mm vs. 4.14 ± 0.44 mm, p < 0.001); and cross-sectional area (7.71 ± 1.68 mm² vs. 8.93 ± 1.30 mm², p < 0.001). Left-right differences were observed in both groups; the left side was generally larger. Receiver operating characteristic curve analysis showed moderate diagnostic performance (area under the curve, 0.66-0.72).
CONCLUSION: The trigeminal nerves in the cisternal region were significantly smaller in patients with FD than in those without FD. These findings may support its potential utility as an imaging biomarker.
METHODS: This retrospective study included 40 patients with FD and 40 age- and sex-matched controls who underwent 3T MRI with constructive interference in steady-state sequence. Two neuroradiologists measured the short-axis length on axial and oblique coronal images and the long-axis length and cross-sectional area on oblique coronal images of the cisternal segment of the trigeminal nerve bilaterally. Morphological differences were assessed between groups and between sides within each group using appropriate t-tests.
RESULTS: All measurements were significantly smaller in the FD group than in the control group: axial images: short-axis length (3.20 ± 0.52 mm vs. 3.51 ± 0.51 mm, p = 0.0101); oblique coronal images: short-axis length (2.41 ± 0.28 mm vs. 2.61 ± 0.35 mm, p = 0.007); long-axis length (3.75 ± 0.53 mm vs. 4.14 ± 0.44 mm, p < 0.001); and cross-sectional area (7.71 ± 1.68 mm² vs. 8.93 ± 1.30 mm², p < 0.001). Left-right differences were observed in both groups; the left side was generally larger. Receiver operating characteristic curve analysis showed moderate diagnostic performance (area under the curve, 0.66-0.72).
CONCLUSION: The trigeminal nerves in the cisternal region were significantly smaller in patients with FD than in those without FD. These findings may support its potential utility as an imaging biomarker.