Internal medicine (Tokyo, Japan) · 2025
Clinical and Pathophysiological Characteristics of Patients in Whom Asthma Developed during Treatment with Immune Checkpoint Inhibitors: A Retrospective Single-center Study.
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Maeno Ken, Tajiri Tomoko, Fukuda Satoshi, Onuki Tomohiro, Ito Keima, Mori Yuta, Fukumitsu Kensuke, Kanemitsu Yoshihiro, Uemura Takehiro, Ohkubo Hirotsugu, Oguri Tetsuya, Niimi Akio
Аннотация
Asthma develops as an immune-related adverse event; however, its clinical and pathophysiological characteristics remain unclear. We retrospectively reviewed five cases of asthma that developed during immune checkpoint inhibitor (ICI) treatment in patients with cancer. In all cases, a significant increase in blood eosinophil count was observed immediately before the onset of asthma symptoms, and serum allergen-specific immunoglobulin E antibodies were positive. ICI treatment could be continued safely, while temporarily suspended in two patients, under asthma treatment. The incidence of asthma was 0.97% (5/514). Early diagnosis and standard treatment enable good asthma control while continuing ICI therapy.