Movement disorders clinical practice · 2026
Convergence Deficits in Myoclonus-Dystonia Point to Cerebellar Impairment.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Gerkensmeier Skadi, Bolte Christina, Radecke Jan-Ole, Hamami Feline, Sprenger Andreas, Helmchen Christoph, Chen Robert, Callister Marcus, Cortez Grippe Talyta, Klein Christine, Brüggemann Norbert, Bäumer Tobias, Münchau Alexander, Weissbach Anne
Аннотация
BACKGROUND: Myoclonus-dystonia (M-D) is a monogenic movement disorder, with proposed cerebellar dysfunction. Vergence eye movement deficits, characteristics of degenerative cerebellar disease, have not been studied in M-D. Cerebellar transcranial alternating current stimulation (tACS) is considered a potential therapeutic approach.
OBJECTIVES: To assess vergence and prosaccade performance as markers of cerebellar dysfunction in M-D and to evaluate the effects of cerebellar 50 Hz tACS on these eye movements.
METHODS: Vergence and prosaccade performance were examined in 14 M-D patients carrying pathogenic SGCE variants and 14 healthy controls. A subgroup (n = 7) received real and sham 50 Hz cerebellar tACS in a randomized, double-blind design.
RESULTS: M-D patients showed prolonged latency and reduced gain of convergence compared to controls. Divergence did not differ between groups. Prosaccade peak velocity was reduced in M-D patients. 50 Hz cerebellar tACS showed no effect on eye movements.
CONCLUSION: Impaired convergence supports cerebellar involvement in M-D. Further studies should identify affected pathways.
OBJECTIVES: To assess vergence and prosaccade performance as markers of cerebellar dysfunction in M-D and to evaluate the effects of cerebellar 50 Hz tACS on these eye movements.
METHODS: Vergence and prosaccade performance were examined in 14 M-D patients carrying pathogenic SGCE variants and 14 healthy controls. A subgroup (n = 7) received real and sham 50 Hz cerebellar tACS in a randomized, double-blind design.
RESULTS: M-D patients showed prolonged latency and reduced gain of convergence compared to controls. Divergence did not differ between groups. Prosaccade peak velocity was reduced in M-D patients. 50 Hz cerebellar tACS showed no effect on eye movements.
CONCLUSION: Impaired convergence supports cerebellar involvement in M-D. Further studies should identify affected pathways.