WMJ : official publication of the State Medical Society of Wisconsin · 2026
Granular Cell Tumor: A Rare Suprasellar Tumor.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Dextre-Espinoza Augusto, Ildefonso-Najarro Sofia, Gonzales Chiroque Fiorella Beatriz, Vasquez Garcia Eric Edwin Edinson, Fuentes-Mendoza Jenyfer María, Concepción-Urteaga Luis, Concepción-Zavaleta Marcio
Аннотация
INTRODUCTION: Granular cell tumors of the neurohypophysis are rare, benign neoplasms originating from pituicytes that often pose diagnostic challenges due to their resemblance to other sellar lesions.
CASE PRESENTATION: We report the case of a 26-year-old man with a 2-year history of headache, polyuria, and hypopituitarism. Magnetic resonance imaging revealed a 21 × 23×30 mm suprasellar mass compressing the optic chiasm and hypothalamus. Hormonal evaluation showed hypogonadotropic hypogonadism, central hypothyroidism, and arginine vasopressin deficiency. The patient underwent partial tumor resection. Histopathology confirmed a grade I granular cell tumor, positive for thyroid transcription factor 1, S100, and vimentin.
DISCUSSION: Granular cell tumors are slow-growing lesions with nonspecific clinical and radiologic features. Diagnosis relies on histologic and immunohistochemical findings. Complete resection is often limited by tumor vascularity and proximity to vital structures.
CONCLUSIONS: Granular cell tumors should be considered in the differential diagnosis of suprasellar tumors. Early recognition and multidisciplinary management may improve patient outcomes.
CASE PRESENTATION: We report the case of a 26-year-old man with a 2-year history of headache, polyuria, and hypopituitarism. Magnetic resonance imaging revealed a 21 × 23×30 mm suprasellar mass compressing the optic chiasm and hypothalamus. Hormonal evaluation showed hypogonadotropic hypogonadism, central hypothyroidism, and arginine vasopressin deficiency. The patient underwent partial tumor resection. Histopathology confirmed a grade I granular cell tumor, positive for thyroid transcription factor 1, S100, and vimentin.
DISCUSSION: Granular cell tumors are slow-growing lesions with nonspecific clinical and radiologic features. Diagnosis relies on histologic and immunohistochemical findings. Complete resection is often limited by tumor vascularity and proximity to vital structures.
CONCLUSIONS: Granular cell tumors should be considered in the differential diagnosis of suprasellar tumors. Early recognition and multidisciplinary management may improve patient outcomes.