Gan to kagaku ryoho. Cancer & chemotherapy · 2025
[A Case of Advanced Gastric Cancer in Which Complete Pathological Response to Pre-Operative SOX and Nivolumab Therapy Was Noted Despite Severe Liver Dysfunction].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Yoneura Naoko, Kondo Eisuke, Nishiya Kei, Ito Katsuhiko, Yokoyama Koya, Shimizu Kimio, Onai Yasuhide, Nakata Yasuyuki, Nakagawa Ayako, Kawahara Kenji, Shimizu Yoshiaki
Аннотация
A 63-year-old man with anemia was diagnosed as having cStage ⅣB gastric cancer with liver metastases. The patient was treated with SOX and nivolumab. After 3 courses of treatment, nivolumab administration was discontinued because of thyroiditis, and SOX was administered for 2 courses. Treatment resulted in RECIST: PR and surgery was planned. An indocyanine green(ICG)clearance test and 99mTc-GSA liver scintigraphy showed poor liver function, and liver biopsy revealed nivolumab-related hepatitis. After the recovery of liver function, the patient underwent total gastrectomy with splenectomy. However, he developed prolonged ascites postoperatively. Hepatitis/hepatotoxicity has been reported as an immune-related adverse event associated with nivolumab administration; however, its effect on surgery remains unknown.