Pharmacological determinants of BIC/FTC/TAF to achieve long term success: potency, genetic barrier and forgiveness.

In the modern ART era, long-term treatment success should be understood as a combination of HIVRNA suppression and a person-centered approach, based on individual therapeutic history, GRT, past toxicities, and comorbidities. The pharmacological determinants of long-term virological suppression are potency, high-genetic barrier, and high-forgiveness regimen. Interplays and relative weights of these three factors can vary according to the different stages of treatment.