Safety of ephedra and related anorexic medications.

BACKGROUND: The increasing incidence of obesity, anorexia and bulimia has resulted in an increased interest in anorexic medications that can modify human eating behaviors. History and medical research is replete with consequences of addressing behavioral disorders with pharmacologic approaches to intervention in the absence of cognitive therapies such as self-efficacy counseling, which we and others have shown to be extremely effective at modifying behaviors previously thought to be resistant to such treatment. This paper looks at some of the ramifications of using anorexic medications, including ephedra, in modern society's efforts to address weight-related health problems.

METHODS: A review of the medical literature about ephedra and related anorexic medications was undertaken as they are linked to eating disorders. The findings included limited evidence of clinical benefit from such medications with concerns over side effects such as cardiovascular, gastrointestinal, CNS and other potential problems. We provide information about current recommendations for using these medications along with concerns for their use.

CONCLUSION: This paper is a review of ephedra and similar anorexic medications and nonprescription substances used in the treatment of obesity and other eating disorders along with some of the potential and proven consequences of such treatment.