[Clinical picture of central nervous system lesions in hematosarcoma].

A description of 21 patients suffering from lympho- and reticulosarcomas with metastatic affections of the cerebral and spinal meninges (20 patients) and an intracerebral solitary tumour (one patient) is presented. In 17 cases the diagnosis was confirmed on autopsy. The neurological picture was similar to the clinical picture of basal (7 patients) or cerebrospinal (9 patients) meningitis. Isolated spinal lesions were infrequent (4 patients). The cerebrospinal liquor showed, as a rule, a protein-cellular dissociation; in individual cases a high blastic pleocytosis was observed. A favourable effect on the disease course was produced by methotrexate which was injected endolumbarly.