Frontiers in neuroscience · 2026
Functional brain network alterations in a rat model of dental malocclusion.
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Lv Qian, Xu Jiali, Zhang Yuejiao, Chen Shuang, Wang Meiqing
Аннотация
BACKGROUND: Malocclusion has been associated with alterations in central nervous system function; however, the effects of persistent abnormal occlusal input on whole-brain functional organization remain poorly understood. This study aimed to investigate functional brain network reorganization associated with unilateral anterior crossbite (UAC) in rats.
METHODS: Fourteen female rats were used, seven of which were treated with left-sided UAC at 6 weeks old and the other seven served as sham-operation controls. Resting-state functional magnetic resonance imaging data were acquired at 26 weeks old. Regional activity in the proprioceptive pathway was assessed, followed by graph theoretical analysis of whole-brain functional networks.
RESULTS: UAC rats exhibited altered regional activity in the right ventral posteromedial thalamus (p = 0.023) and primary somatosensory cortex (p < 0.001), contralateral to the modeling side. Network analysis revealed significantly higher normalized clustering coefficient (p = 0.014) and small-worldness (p = 0.006) in the UAC group compared with controls. Furthermore, UAC rats showed enhanced functional connectivity within a subnetwork (p = 0.023) in which the right amygdala exhibited the greatest number of altered connections. In addition, abnormal regional activity was also detected in the right amygdala of UAC rats (p = 0.039).
CONCLUSION: Long-term UAC in rats is associated with alterations in whole-brain functional network organization. These findings provide new insights into the central neural responses associated with abnormal occlusal input.
METHODS: Fourteen female rats were used, seven of which were treated with left-sided UAC at 6 weeks old and the other seven served as sham-operation controls. Resting-state functional magnetic resonance imaging data were acquired at 26 weeks old. Regional activity in the proprioceptive pathway was assessed, followed by graph theoretical analysis of whole-brain functional networks.
RESULTS: UAC rats exhibited altered regional activity in the right ventral posteromedial thalamus (p = 0.023) and primary somatosensory cortex (p < 0.001), contralateral to the modeling side. Network analysis revealed significantly higher normalized clustering coefficient (p = 0.014) and small-worldness (p = 0.006) in the UAC group compared with controls. Furthermore, UAC rats showed enhanced functional connectivity within a subnetwork (p = 0.023) in which the right amygdala exhibited the greatest number of altered connections. In addition, abnormal regional activity was also detected in the right amygdala of UAC rats (p = 0.039).
CONCLUSION: Long-term UAC in rats is associated with alterations in whole-brain functional network organization. These findings provide new insights into the central neural responses associated with abnormal occlusal input.