ILUSY+ Study: Spectacle independence and visual quality of life after bilateral implantation of Synthesis+ versus monofocal intraocular lenses.

PURPOSE: To compare patients' spectacle independence and satisfaction after implantation of EDOF IOLs versus monofocal IOLs.

DESIGN

Prospective, non-randomized, comparative, two-center study.

SETTING

Rennes University Hospital and Lorient Hospital, France.

METHODS

Nineteen patients underwent bilateral implantation of the Synthesis+ IOL, and thirty-five underwent bilateral implantation of monofocal IOLs. Best-corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA) at 4 meters, corrected (CNVA) and uncorrected near visual acuity (UNVA) at 33cm, were assessed at 1 and 6 months after the surgery. Defocus curves and Pelli-Robson contrast sensitivity testing in photopic conditions were performed 1 month postoperatively. Patient-reported spectacle independence was evaluated by the PRSI-Q, and visual function and satisfaction by the Catquest-9SF preoperatively and at 1 and 6 months postoperatively. A P-value less than 0.05 was considered statistically significant.

RESULTS

The mean UDVA (P=0.0523), CDVA (P=0.53) and contrast sensitivity (P=0.9248) did not differ between groups. UNVA was significantly better in the Synthesis+ group (0.39±0.18 vs 0.63±0.16 P<0.0001). The defocus curves show an extended depth of focus of 2D for a visual acuity better than 0.3 logMAR. Spectacle independence was significantly higher for intermediate (P=0.0002) and near vision (P=0.0006), with better visual comfort in the Synthesis+ group as well as higher global satisfaction (P=0.0155).

CONCLUSION

The Synthesis+ IOL provides an extended depth of focus and UNVA significantly higher than that of monofocal IOLs, without a corresponding loss of contrast sensitivity and distance visual acuity. As a result, it enhances spectacle independence, particularly in social settings, and leads to higher overall satisfaction among patients.