A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

Virolainen Samuel J, Creighton Kathryn, Dashtiahangar Maryam, Krishnamurthy Durga, Parks Lois, Forney Carmy, Ampadu Britney, Rudrapatna Akshata N, Dunn Katelyn A, Parameswaran Sreeja, Hesse Hayley K, Chen Xiaoting, VonHandorf Andrew, Edsall Lee E, Yin Cailing, Lynch Arthur, Gittens Olivia, Diouf Arame A, Jones Sydney H, Hass Matthew, Javier Ellen, Donmez Omer, Keddari Yasine, Danzinger Oded, Seelamneni Harsha, Namjou-Khales Bahram, Ainsworth Hannah C, Comeau Mary E, Marion Miranda C, Glenn Stuart B, Nath Swapan K, Freedman Barry I, Tsao Betty P, Kamen Diane L, Brown Elizabeth E, Gilkeson Gary S, Alarcón Graciela S, Reveille John D, James Judith A, Criswell Lindsey A, Vilá Luis M, Alarcón-Riquelme Marta E, Petri Michelle, Scofield R Hal, Kimberly Robert P, Ramsey-Goldman Rosalind, Bae Sang-Cheol, Graham Deborah Cunninghame, Vyse Timothy J, Guthridge Joel M, Gaffney Patrick M, Langefeld Carl D, Kelly Jennifer A, Kaufman Kenneth M, Sivils Kathy L, Harley John B, Shen Nan, Lawson Lucinda P, Baglaenko Yuriy, Miraldi Emily R, Rosenberg Brad R, Siggers Trevor, Waggoner Stephen N, Weirauch Matthew T, Kottyan Leah C

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