Journal of arrhythmia · 2026
Glucagon-Like Peptide-1 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes.
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Rassam Farah, Lopez Esteban Kosak, Sass Sarah, Srikulmontri Thitiphan, Isaacs Evan, Malin John, Wattanachayakul Phuuwadith, Afolabi-Brown Olayinka
Аннотация
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce cardiovascular risk in obesity, but their effect on atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) remains unclear.
METHODS: We analyzed TriNetX data comparing obese, non-diabetic HFpEF patients treated with GLP-1 RAs (n = 478) with untreated patients (n = 6887). Propensity matching yielded 470 patients per cohort.
RESULTS: GLP-1 RA therapy was not associated with reduced AF incidence (HR 0.86; 95% CI, 0.53-1.39; p = 0.543) but was associated with lower mortality (HR 0.42; 95% CI, 0.23-0.75; p = 0.003).
CONCLUSIONS: GLP-1 RAs may not reduce AF incidence in obese, HFpEF patients.
METHODS: We analyzed TriNetX data comparing obese, non-diabetic HFpEF patients treated with GLP-1 RAs (n = 478) with untreated patients (n = 6887). Propensity matching yielded 470 patients per cohort.
RESULTS: GLP-1 RA therapy was not associated with reduced AF incidence (HR 0.86; 95% CI, 0.53-1.39; p = 0.543) but was associated with lower mortality (HR 0.42; 95% CI, 0.23-0.75; p = 0.003).
CONCLUSIONS: GLP-1 RAs may not reduce AF incidence in obese, HFpEF patients.