Медицинская библиотека · The American journal of psychiatry · 2026

Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group.

Hinojosa Cecilia A, Sun Delin, Russell Courtney, Baird C Lexi, Hussain Ahmed, Sendi Mohammad, Jahanshad Neda, Salminen Lauren E, Olff Miranda, Frijling Jessie L, Veltman Dick J, Koch Saskia B J, Nawijn Laura, van Zuiden Mirjam, Wang Li, Zhu Ye, Li Gen, Stein Dan J, Ipser Jonathan, Koopowitz Sheri-Michelle, Neria Yuval, Zhu Xi, Ravid Orren, Zilcha-Mano Sigal, Lazarov Amit, Suarez-Jimenez Benjamin, Huggins Ashley A, Ressler Kerry, Jovanovic Tanja, Fani Negar, Mueller Sven C, Hudson Anna R, Daniels Judith K, Sierk Anika, Manthey Antje, Walter Henrik, van der Wee Nic J A, van der Werff Steven J A, Vermeiren Robert R J M, Rektor Ivan, Říha Pavel, Kaufman Milissa L, Lebois Lauren A M, Baker Justin T, King Anthony, Liberzon Israel, Angstadt Mike, Davenport Nicholas D, Disner Seth G, Sponheim Scott R, Straube Thomas, Hofmann David, Lu Guang Ming, Qi Rongfeng, Wang Xin, Kunch Austin, Xie Hong, Quidé Yann, El-Hage Wissam, Lissek Shmuel, Berg Hannah, Cisler Josh, Ross Marisa, Herringa Ryan J, Grupe Daniel W, Nitschke Jack B, Davidson Richard J, Larson Christine L, deRoon-Cassini Terri A, Tomas Carissa W, Fitzgerald Jacklynn M, Feola Brandee, Urbano-Blackford Jennifer, Olatunji Bunmi O, May Geoffrey, Nelson Steven M, Gordon Evan M, Abdallah Chadi G, Lanius Ruth, Densmore Maria, Théberge Jean, Neufeld Richard W J, Baugh Lee A, Simons Raluca M, Simons Jeffrey S, Magnotta Vincent A, Fercho Kelene A, Elman Jeremy, Panizzon Matthew, Franz Carol, Lyons Michael J, Kremen William, McLaughin Katie A, Peverill Matthew, Sambrook Kelly, Thompson Paul M, Stevens Jennifer S, Morey Rajendra A, van Rooij Sanne J H

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Аннотация

OBJECTIVE

Studies investigating resting-state functional connectivity of the amygdala and hippocampus have produced inconsistent findings. The authors' objective was to conduct the largest systematic comparison of alterations in functional connectivity of the amygdala and hippocampus in individuals with posttraumatic stress disorder (PTSD) using a multicohort mega-analysis with uniform processing steps and parameters across all cohorts.

METHODS

Resting-state functional MRI data from 1,017 PTSD patients and 1,702 control participants from 32 international sites were centrally preprocessed with HALFpipe and analyzed using the Image-Based Meta- and Mega-Analysis (IBMMA) package for neuroimaging processing. Group-level seed-based whole-brain analyses were completed for the right and left amygdala and hippocampus. Additional correlation analyses were conducted between PTSD norm-severity scores and resting-state functional connectivity (rs-FC).

RESULTS

Compared to control participants, individuals with PTSD showed stronger rs-FC between the left amygdala seed and right hippocampus and amygdala and the left and right lingual gyri. Greater PTSD total norm-severity scores were significantly associated with rs-FC between the left amygdala and right hippocampus/amygdala and rs-FC between the right amygdala and left hippocampus/amygdala.

CONCLUSIONS

Greater connectivity between subcortical threat centers involved in fear processing, memory, and extinction learning characterizes the resting state in PTSD. Future directions include investigating how different interventions, such as brain stimulation, neurofeedback, and psychotherapy, might modulate the aberrant neural networks in PTSD.

Для цитирования: Hinojosa Cecilia A, Sun Delin, Russell Courtney, Baird C Lexi, Hussain Ahmed, Sendi Mohammad, Jahanshad Neda, Salminen Lauren E, Olff Miranda, Frijling Jessie L, Veltman Dick J, Koch Saskia B J, Nawijn Laura, van Zuiden Mirjam, Wang Li, Zhu Ye, Li Gen, Stein Dan J, Ipser Jonathan, Koopowitz Sheri-Michelle, Neria Yuval, Zhu Xi, Ravid Orren, Zilcha-Mano Sigal, Lazarov Amit, Suarez-Jimenez Benjamin, Huggins Ashley A, Ressler Kerry, Jovanovic Tanja, Fani Negar, Mueller Sven C, Hudson Anna R, Daniels Judith K, Sierk Anika, Manthey Antje, Walter Henrik, van der Wee Nic J A, van der Werff Steven J A, Vermeiren Robert R J M, Rektor Ivan, Říha Pavel, Kaufman Milissa L, Lebois Lauren A M, Baker Justin T, King Anthony, Liberzon Israel, Angstadt Mike, Davenport Nicholas D, Disner Seth G, Sponheim Scott R, Straube Thomas, Hofmann David, Lu Guang Ming, Qi Rongfeng, Wang Xin, Kunch Austin, Xie Hong, Quidé Yann, El-Hage Wissam, Lissek Shmuel, Berg Hannah, Cisler Josh, Ross Marisa, Herringa Ryan J, Grupe Daniel W, Nitschke Jack B, Davidson Richard J, Larson Christine L, deRoon-Cassini Terri A, Tomas Carissa W, Fitzgerald Jacklynn M, Feola Brandee, Urbano-Blackford Jennifer, Olatunji Bunmi O, May Geoffrey, Nelson Steven M, Gordon Evan M, Abdallah Chadi G, Lanius Ruth, Densmore Maria, Théberge Jean, Neufeld Richard W J, Baugh Lee A, Simons Raluca M, Simons Jeffrey S, Magnotta Vincent A, Fercho Kelene A, Elman Jeremy, Panizzon Matthew, Franz Carol, Lyons Michael J, Kremen William, McLaughin Katie A, Peverill Matthew, Sambrook Kelly, Thompson Paul M, Stevens Jennifer S, Morey Rajendra A, van Rooij Sanne J H. Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group.. The American journal of psychiatry. 2026. DOI: 10.1176/appi.ajp.20250062.

Предметные рубрики MeSH

Humans Stress Disorders, Post-Traumatic Amygdala Hippocampus Magnetic Resonance Imaging Male Adult Female Middle Aged Neural Pathways Connectome Case-Control Studies

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