Annals of vascular surgery · 2026
Association between Lactate-to-Albumin Ratio and 28-day In-Hospital Poor Outcomes in Acute Limb Ischemia: A Multicenter Cohort Study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Feng Yuan, An Hongfei, Wu Mengchao, Lu Jinghan, Geng Yihe, Gao Xuanzhe, Zhao Zezheng, Li Yaling, Wang Shuo, Rong Zhihua, Chen Zhong, Yang Yaoguo
Аннотация
BACKGROUND: The lactate-to-albumin ratio (LAR) is a novel prognostic marker in conditions such as respiratory failure and sepsis, but its value in acute lower limb ischemia (ALI) remains unclear.
METHODS: ALI patients were retrospectively enrolled from our hospital and the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. LAR was the exposure of interest, and the primary outcome was in-hospital adverse events, defined as death or amputation within 28 days.
RESULTS: In the inner cohort, 18 patients experienced adverse events and 93 did not. In the MIMIC cohort, 73 had adverse events and 154 served as controls. Multivariable Cox regression in both cohorts showed that higher LAR was independently associated with increased risk of in-hospital adverse events. LAR demonstrated moderate discrimination, with an area under the curve of 0.762 in the inner cohort and 0.647 in the MIMIC cohort. Subgroup analyses found no significant interactions in the inner cohort. In the MIMIC cohort, the association between LAR and adverse events was stronger in patients without atrial fibrillation (hazard ratio [HR] = 1.69) than in those with atrial fibrillation (HR = 1.25).
CONCLUSIONS: LAR was independently associated with in-hospital death or amputation in patients with ALI.
METHODS: ALI patients were retrospectively enrolled from our hospital and the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. LAR was the exposure of interest, and the primary outcome was in-hospital adverse events, defined as death or amputation within 28 days.
RESULTS: In the inner cohort, 18 patients experienced adverse events and 93 did not. In the MIMIC cohort, 73 had adverse events and 154 served as controls. Multivariable Cox regression in both cohorts showed that higher LAR was independently associated with increased risk of in-hospital adverse events. LAR demonstrated moderate discrimination, with an area under the curve of 0.762 in the inner cohort and 0.647 in the MIMIC cohort. Subgroup analyses found no significant interactions in the inner cohort. In the MIMIC cohort, the association between LAR and adverse events was stronger in patients without atrial fibrillation (hazard ratio [HR] = 1.69) than in those with atrial fibrillation (HR = 1.25).
CONCLUSIONS: LAR was independently associated with in-hospital death or amputation in patients with ALI.
Предметные рубрики MeSH
HumansFemaleRetrospective StudiesIschemiaTime FactorsRisk FactorsMaleBiomarkersAgedHospital MortalityAmputation, SurgicalAcute DiseasePredictive Value of TestsLactic AcidPeripheral Arterial DiseaseDatabases, FactualAged, 80 and overSerum Albumin, HumanMiddle AgedProportional Hazards ModelsTreatment OutcomeMultivariate AnalysisLower ExtremityRisk AssessmentLimb SalvageKaplan-Meier Estimate