Translational vision science & technology · 2026
Design and Preclinical Validation of an Eyeglass-Coupled Perilimbal Antenna for Retinal Prostheses With a Biocompatible Graft Technique.
СтатьяНазвание и аннотация: Перевод в очереди
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Lee Cheng-Yung, Lai Tso-Ting, Chiang Chien-Yu, Wang Yun-Chen, Lin San-Yuan, Chiang Yi-Ju, Yang Yun-Ta, Yang Chang-Hao, Fan Long-Sheng
Аннотация
PURPOSE: To present a novel eyeglass-coupled perilimbal antenna for retinal prostheses and evaluate preclinical biocompatibility and ocular surface effects using a refined, graft-assisted implantation technique.
METHODS: The structural, mechanical, and functional properties of the antenna were assessed, including buffering systems for tissue resilience. Coupling between the eyeglass-rim-mounted emitter and perilimbal receiver was optimized through finite-element electromagnetic simulation and validated in electrolyte solution. A preclinical study was performed in 11 eyes of six Lanyu minipigs, in which antennas were implanted using a refined surgical technique and covered with amniotic membrane, porcine small intestinal submucosa, or pericardium graft. Postoperative evaluations over 6 months included serial external eye photography, anterior segment optical coherence tomography (AS-OCT), tear secretion testing, tear cytokine profiling, and conjunctival impression cytology.
RESULTS: All eyes showed stable healing without exposure, infection, or granulation. ASOCT revealed no significant change in perilimbal conjunctival thickness (400.5 ± 89.6 µm baseline vs. 399.4 ± 158.2 µm at 6 months; P = 0.612). Coverage materials thinned significantly (360.7 ± 119.5 µm at 1 month vs. 71.4 ± 103.0 µm at 6 months; P = 0.018) without adverse ocular effects. Transient postoperative elevations of tear cytokines (IL-1β, IL-8, IL-6) normalized over time. Tear production, conjunctival redness, and goblet cell density returned to baseline levels.
CONCLUSIONS: The eyeglass-coupled perilimbal antenna enabled efficient transmission with preserved ocular surface integrity. Graft-assisted implantation ensured stability and biocompatibility, serving as a safe interface for retinal prostheses.
TRANSLATIONAL RELEVANCE: A novel perilimbal antenna design enables efficient wireless transmission and biocompatible integration for next-generation retinal prostheses.
METHODS: The structural, mechanical, and functional properties of the antenna were assessed, including buffering systems for tissue resilience. Coupling between the eyeglass-rim-mounted emitter and perilimbal receiver was optimized through finite-element electromagnetic simulation and validated in electrolyte solution. A preclinical study was performed in 11 eyes of six Lanyu minipigs, in which antennas were implanted using a refined surgical technique and covered with amniotic membrane, porcine small intestinal submucosa, or pericardium graft. Postoperative evaluations over 6 months included serial external eye photography, anterior segment optical coherence tomography (AS-OCT), tear secretion testing, tear cytokine profiling, and conjunctival impression cytology.
RESULTS: All eyes showed stable healing without exposure, infection, or granulation. ASOCT revealed no significant change in perilimbal conjunctival thickness (400.5 ± 89.6 µm baseline vs. 399.4 ± 158.2 µm at 6 months; P = 0.612). Coverage materials thinned significantly (360.7 ± 119.5 µm at 1 month vs. 71.4 ± 103.0 µm at 6 months; P = 0.018) without adverse ocular effects. Transient postoperative elevations of tear cytokines (IL-1β, IL-8, IL-6) normalized over time. Tear production, conjunctival redness, and goblet cell density returned to baseline levels.
CONCLUSIONS: The eyeglass-coupled perilimbal antenna enabled efficient transmission with preserved ocular surface integrity. Graft-assisted implantation ensured stability and biocompatibility, serving as a safe interface for retinal prostheses.
TRANSLATIONAL RELEVANCE: A novel perilimbal antenna design enables efficient wireless transmission and biocompatible integration for next-generation retinal prostheses.