Annals of clinical and translational neurology · 2026
Posterior Cortical Atrophy in the Asia-Pacific: A Report From the PCA Asian Workgroup.
СтатьяНазвание и аннотация: Перевод в очереди
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Likitjaroen Yuttachai, Chang Ya-Ting, Lim Levinia, Chiu Pai-Yi, Hsu Jung-Lung, Kim SangYun, Narita Wataru, Ryoo Na Young, Suzuki Kyoko, Kandiah Nagaendran, Crutch Sebastian, Pai Ming-Chyi
Аннотация
OBJECTIVE: Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA-pure and PCA-plus syndromes based on consensus criteria. To address this, the PCA Asia Workgroup was established to study PCA in Asian countries.
METHODS: The Asia PCA Workgroup collected demographic and clinical data, including symptoms and signs, from PCA patients. Patients were classified into PCA-pure (solely meeting PCA criteria) and PCA-plus (additional features of other neurodegenerative syndromes). The frequency of clinical presentations, symptoms, and signs was compared to the consensus classification estimation and the meta-analysis of published data.
RESULTS: PCA-pure (76.2%) was the most common subtype, with earlier onset (80.95%) and distinct early prominent deficit of executive/memory > visual disturbances which is different from the consensus study has estimated and the meta-analysis of published data. PCA-Lewy body disease (PCA-DLB) exhibited higher frequencies of attention deficits, visual hallucinations, cognitive fluctuations, and rigidity compared to PCA-pure.
INTERPRETATION: This study reveals the real-world clinical presentation of PCA syndrome in an Asian population, emphasizing the differences from consensus estimations and the meta-analysis of published data. Further research is needed to validate these findings and compare them with real clinical data from PCA patients of other ethnicities, in order to gain a comprehensive understanding of PCA worldwide.
METHODS: The Asia PCA Workgroup collected demographic and clinical data, including symptoms and signs, from PCA patients. Patients were classified into PCA-pure (solely meeting PCA criteria) and PCA-plus (additional features of other neurodegenerative syndromes). The frequency of clinical presentations, symptoms, and signs was compared to the consensus classification estimation and the meta-analysis of published data.
RESULTS: PCA-pure (76.2%) was the most common subtype, with earlier onset (80.95%) and distinct early prominent deficit of executive/memory > visual disturbances which is different from the consensus study has estimated and the meta-analysis of published data. PCA-Lewy body disease (PCA-DLB) exhibited higher frequencies of attention deficits, visual hallucinations, cognitive fluctuations, and rigidity compared to PCA-pure.
INTERPRETATION: This study reveals the real-world clinical presentation of PCA syndrome in an Asian population, emphasizing the differences from consensus estimations and the meta-analysis of published data. Further research is needed to validate these findings and compare them with real clinical data from PCA patients of other ethnicities, in order to gain a comprehensive understanding of PCA worldwide.