Liver failure and the need for transplantation in three patients with hepatoportal sclerosis.

Hepatoportal sclerosis (HPS) is one of the causes of noncirrhotic portal hypertension. In most patients, hepatic synthetic dysfunction does not occur; rarely they may require liver transplantation. In this study, we have reported the clinicopathologic characteristics of 3 patients diagnosed with HPS after examination of the explanted liver. Small liver volume, significant portal fibrosis, and phlebosclerosis may contribute to hepatic synthetic dysfunction in patients with HPS.