Journal of ethnopharmacology · 2026
Buyiniuxi pill promotes hair regrowth in a DHT-induced mouse model of androgenetic alopecia.
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Pang Wei, Zhang Yu Huan, Cheng Xiao Xia, Chen Jing, Li Xiao Qiang
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Buyiniuxi pill (BYNX) is a classical traditional Chinese medicine (TCM) formula first recorded in Taiping Shenghui Fang (AD 992) and has been traditionally prescribed for hair loss and premature hair greying. Its constituent herbs remain relevant in contemporary ethnopharmacological practice for hair regeneration.
AIM OF THE STUDY: This study aimed to evaluate the hair regrowth-promoting effects of BYNX in a dihydrotestosterone (DHT)-induced murine model of androgenetic alopecia (AGA) and to explore its potential molecular mechanisms.
MATERIALS AND METHODS: The chemical profile of the BYNX aqueous extract was characterized using UHPLC-Orbitrap-MS. Network pharmacology was used to explore potential targets and pathways associated with AGA. In vivo efficacy was assessed in a DHT-induced murine model following oral administration of BYNX at low or high doses. Hair regrowth was evaluated by hair length and hair coverage percentage, while histopathology, immunohistochemistry, ELISA, and RT-qPCR were performed to investigate underlying mechanisms.
RESULTS: UHPLC-Orbitrap-MS analysis revealed a chemically complex profile of BYNX, and representative constituents were selected for subsequent network pharmacology analysis. Predicted targets were mainly enriched in inflammation-related biological processes and the PI3K-AKT signaling pathway. In vivo, BYNX significantly alleviated DHT-induced hair growth inhibition, as evidenced by increased hair length, improved hair coverage, and restoration of hair follicle morphology. These changes were accompanied by reduced IL-6 and IL-4 expression, enhanced activation of the AKT/BCL-2 signaling pathway, and increased Cyclin D1 and β-catenin expression in dorsal skin tissue.
CONCLUSIONS: BYNX significantly promotes hair regrowth in a DHT-induced murine model of AGA. The hair-regenerative effects of BYNX were associated with modulation of inflammatory responses and activation of AKT/BCL-2-related survival signaling, suggesting a multi-target regulatory pattern consistent with its traditional ethnopharmacological use.
AIM OF THE STUDY: This study aimed to evaluate the hair regrowth-promoting effects of BYNX in a dihydrotestosterone (DHT)-induced murine model of androgenetic alopecia (AGA) and to explore its potential molecular mechanisms.
MATERIALS AND METHODS: The chemical profile of the BYNX aqueous extract was characterized using UHPLC-Orbitrap-MS. Network pharmacology was used to explore potential targets and pathways associated with AGA. In vivo efficacy was assessed in a DHT-induced murine model following oral administration of BYNX at low or high doses. Hair regrowth was evaluated by hair length and hair coverage percentage, while histopathology, immunohistochemistry, ELISA, and RT-qPCR were performed to investigate underlying mechanisms.
RESULTS: UHPLC-Orbitrap-MS analysis revealed a chemically complex profile of BYNX, and representative constituents were selected for subsequent network pharmacology analysis. Predicted targets were mainly enriched in inflammation-related biological processes and the PI3K-AKT signaling pathway. In vivo, BYNX significantly alleviated DHT-induced hair growth inhibition, as evidenced by increased hair length, improved hair coverage, and restoration of hair follicle morphology. These changes were accompanied by reduced IL-6 and IL-4 expression, enhanced activation of the AKT/BCL-2 signaling pathway, and increased Cyclin D1 and β-catenin expression in dorsal skin tissue.
CONCLUSIONS: BYNX significantly promotes hair regrowth in a DHT-induced murine model of AGA. The hair-regenerative effects of BYNX were associated with modulation of inflammatory responses and activation of AKT/BCL-2-related survival signaling, suggesting a multi-target regulatory pattern consistent with its traditional ethnopharmacological use.