Guillain-Barré Syndrome Following Seasonal Coronavirus (HCoV-229E) Infection: A Case Managed Without Intensive Care.

Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy often preceded by infection. We report the case of a 49-year-old man presenting with subacute, progressive, symmetric ascending weakness involving the lower and distal upper extremities, ultimately diagnosed with GBS, triggered by human coronavirus 229E infection. The patient was managed with intravenous immunoglobulin (IVIG) and close respiratory monitoring in a stepdown unit without progression to respiratory failure or need for intensive care unit (ICU) admission. This case highlights diagnostic considerations, the role of electrophysiologic testing, and ICU triage decision-making in suspected GBS.