International journal of dermatology · 2018
Squamous cell carcinoma of the nail unit: a retrospective review of 19 cases in Asia and comparative review of Western literature.
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Lee Tae-Min, Jo Gwanghyun, Kim Minsoo, Lee Si-Hyung, Cho Soo Ick, Jo Seong J, Mun Je-Ho
Аннотация
BACKGROUND: Reports regarding squamous cell carcinoma of the nail unit (SCCnu) are rare in Asia.
OBJECTIVES: To investigate the features of SCCnu in the Asian population.
METHOD: We performed a retrospective review of patients diagnosed with SCCnu at our institution between 2012 and 2017.
RESULTS: Nineteen cases were included. Thirteen patients were male (68.4%). The fingers were most frequently affected (73.7%). Mean delay to diagnosis was 62.4 months. Misdiagnosis rate was high (78.9%). Frequent clinical features were subungual tumor, subungual hyperkeratosis, nail dystrophy, ulcer, and nail loss. The majority of cases were invasive SCC in 15 cases (78.9%), while SCC in situ was found in four cases (21.1%). Local recurrence was detected in two cases (10.5%) following surgical resection. However, distant metastasis was not reported.
CONCLUSION: This study provides data of 19 SCCnu cases in Asia. Clinical characteristics of SCCnu in this study were similar to those of reports from Western countries. However, we found a higher frequency of more invasive cases and longer delay to diagnosis in our study; this advocates the need for greater attention on nail disorders among healthcare providers, particularly in Asia.
OBJECTIVES: To investigate the features of SCCnu in the Asian population.
METHOD: We performed a retrospective review of patients diagnosed with SCCnu at our institution between 2012 and 2017.
RESULTS: Nineteen cases were included. Thirteen patients were male (68.4%). The fingers were most frequently affected (73.7%). Mean delay to diagnosis was 62.4 months. Misdiagnosis rate was high (78.9%). Frequent clinical features were subungual tumor, subungual hyperkeratosis, nail dystrophy, ulcer, and nail loss. The majority of cases were invasive SCC in 15 cases (78.9%), while SCC in situ was found in four cases (21.1%). Local recurrence was detected in two cases (10.5%) following surgical resection. However, distant metastasis was not reported.
CONCLUSION: This study provides data of 19 SCCnu cases in Asia. Clinical characteristics of SCCnu in this study were similar to those of reports from Western countries. However, we found a higher frequency of more invasive cases and longer delay to diagnosis in our study; this advocates the need for greater attention on nail disorders among healthcare providers, particularly in Asia.