Internal medicine (Tokyo, Japan) · 2023
Lambert-Eaton Myasthenic Syndrome Complicated by Anti-GABAB Receptor Encephalitis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yamada Kazuki, Yaguchi Hiroaki, Ishikawa Kaede, Tanaka Daiki, Oshima Yuki, Mizushima Keiichi, Uwatoko Hisashi, Shirai Shinichi, Takahashi-Iwata Ikuko, Matsushima Masaaki, Tanaka Keiko, Yabe Ichiro
Аннотация
A 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis.