Radiology case reports · 2023
Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Otani Michimi, Nishimori Miki, Iwasa Hitomi, Iwamura Mamiko, Izumi Takayasu, Nakaji Kosuke, Nitta Noriko, Miyatake Kana, Yoshimatsu Rika, Yamanishi Tomoaki, Matsumoto Tomohiro, Osaki Yasushi, Wada Noriko, Toi Makoto, Yamamoto Marino, Nakatani Yu, Kubota Tetsuya, Yamagami Takuji
Аннотация
Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible factor in the SR of cancer associated with PNS. We herein report the first case of SR of SCLC combined with anti-P/Q-type of voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS), a subtype of PNS. This case report suggests that SCLC may be spontaneously reduced by an autoimmune response induced by VGCC antibodies associated with LEMS. Our finding may help elucidate the mechanisms that inhibit tumor growth and cause the regression of tumors.