Dimensional Associations Between Conduct Problems and Brain Structure Across 18 International Cohorts in ENIGMA.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Staginnus Marlene, Gao Yidian, Townend Sophie, Zugman Andre, Zhang Jibiao, Wu Qiong, Westerman Heidi B, Viding Essi, Vermeiren Robert R J M, van der Wee Nic J A, Townsend Christopher D, Sun Xiaoqiang, Sully Kate, Sukhodolsky Denis, Stadler Christina, Sonuga-Barke Edmund J S, Smaragdi Areti, Sethi Arjun, Schumann Gunter, Schulze Ulrike M E, Santosh Paramala, Salum Giovanni A, Sagar-Ouriaghli Ilyas, Rogers Jack C, Roberts Ruth, Raschle Nora M, Ploe Montana L, Phillips Harriet, Penzol Maria J, Pauli Ruth, Pan Pedro M, Oosterling Maaike, Mycue Leah Elena, Murphy Declan G M, Monk Christopher S, Mitchell Colter, Ming Qingsen, Michalska Kalina J, Martinot Jean-Luc, Martinelli Anne, Marsh Abigail A, Ma Ren, Lamers Kim, Kypta-Vivanco Alexandra, Konrad Kerstin, Kohls Gregor, Jiang Yali, Jackson Rebecca, Jackowski Andrea, Jabeen Nimrah, Ibrahim Karim, Hyde Luke W, Holla Bharath, Hoekstra Pieter J, González-Madruga Karen, Glennon Jeffrey C, Freitag Christine M, Franke Barbara, Dykstra Anouk H, Dong Daifeng, Dietrich Andrea, Díaz Dana E, Desrivières Sylvane, De La Serna Elena, Cubillo Ana I, Craig Michael C, Cornwell Harriet, Colins Olivier F, Chester Sally C, Castro-Fornieles Josefina, Cardinale Elise M, Burt S Alexandra, Buitelaar Jan K, Brandeis Daniel, Bokde Arun L W, Boateng Charlotte P S, Blair Robert J R, Bernhard Anka, Berluti Kathryn, Benegal Vivek, Banaschewski Tobias, Bajaj Sahil, Arango Celso, Jahanshad Neda, Thomopoulos Sophia I, Ching Christopher R K, Kang Melody J Y, Thompson Paul M, Aghajani Moji, Baskin-Sommers Arielle, Cecil Charlotte A M, Dugré Jules R, Klapwijk Eduard T, Pine Daniel S, Walton Esther, De Brito Stephane A, Fairchild Graeme
Аннотация
METHOD: T1-weighted structural brain magnetic resonance imaging scans from 14,160 youths (5-21 years old, 46.2% female) across 18 international case-control, community-based, and population-based cohorts were preprocessed using ENIGMA-standardized protocols. Regression models examined associations between CPs and cortical thickness, surface area, and subcortical volumes, adjusting for age, sex, and intracranial volume. Moderation by sex, age, and callous-unemotional traits was also investigated.
RESULTS: Widespread but small (β = -0.02 to -0.07) negative associations were observed between CPs and surface area (total surface area, 23/34 regions), cortical thickness (average thickness, 15/34 regions), and amygdalar and hippocampal volumes. Sex was a key moderator, with many surface area associations limited to boys and some thickness associations limited to girls. Some associations were stronger in younger children and at lower levels of callous-unemotional traits. The impact of adjusting for IQ and other psychopathology varied by outcome (eg, most surface area findings survived IQ adjustment, whereas cortical thickness associations did not).
CONCLUSION: CPs were associated with subtle, yet widespread, alterations in brain structure. Findings overlapped with differences observed in categorically measured conduct disorder, but novel associations with cortical thickness were identified. This provides further evidence that neuroanatomical differences are not limited to youth with clinically elevated CPs. Our findings have potential implications for neurocognitive models of CPs as they extend beyond the regions highlighted in these models.
STUDY REGISTRATION INFORMATION: Investigating dimensional relationships between conduct problems and brain structure: an ENIGMA mega-analysis; https://osf.io/nzj3r/.