The International journal of neuroscience · 2026
From imaging to molecular pathways: a comprehensive narrative review of the distinctive landscape of secretory meningioma.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Shahabinejad Erfan, Kamali Mahsa, Shakoeizadeh Amirreza, Falakian Zeinab, Foroughi Eghbal Aynaz, Alipour Seyyed Mohammad, Krywyj Maria, Sheehan Jason P, Alrashidi Qais, Borghei-Razavi Hamid
Аннотация
BACKGROUND: Secretory meningioma (SM) is an uncommon variety of meningioma, representing about 1-3% of cases. Notwithstanding its benign classification, SM is frequently associated with excessive peritumoral brain edema (PTBE), resulting in considerable morbidity. This study examines the epidemiology, clinical presentation, imaging characteristics, histological features, immuno-histochemical profile and genetic landscape of SM, along with management methods and results.
MATERIALS AND METHODS: We performed a structured search in PubMed, Scopus, and Web of Science up up to October 2025 using keywords including "secretory meningioma" "meningioma", "peritumoral brain edema", and related terms. Original and review articles in English were included. Relevant data were extracted and narratively synthesized covering clinical, radiological, pathological, and genetic features.
RESULTS: SM is defined by the presence of pseudopsammoma bodies, pronounced immunoreactivity for carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA), and a unique molecular profile featuring KLF4 K409Q and TRAF7 mutations. Radiologically, PTBE is characterized by fluid-attenuated inversion recovery (FLAIR) hyperintensity and increased apparent diffusion coefficient (ADC) values serves as critical diagnostic indicators. While surgical gross complete resection is the gold standard, significant postoperative tumor bed edema complicates perioperative treatment and may necessitate additional therapies.
CONCLUSION: Identifying SM as a unique clinical entity is essential for diagnosis, prognosis and therapeutic approaches.
MATERIALS AND METHODS: We performed a structured search in PubMed, Scopus, and Web of Science up up to October 2025 using keywords including "secretory meningioma" "meningioma", "peritumoral brain edema", and related terms. Original and review articles in English were included. Relevant data were extracted and narratively synthesized covering clinical, radiological, pathological, and genetic features.
RESULTS: SM is defined by the presence of pseudopsammoma bodies, pronounced immunoreactivity for carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA), and a unique molecular profile featuring KLF4 K409Q and TRAF7 mutations. Radiologically, PTBE is characterized by fluid-attenuated inversion recovery (FLAIR) hyperintensity and increased apparent diffusion coefficient (ADC) values serves as critical diagnostic indicators. While surgical gross complete resection is the gold standard, significant postoperative tumor bed edema complicates perioperative treatment and may necessitate additional therapies.
CONCLUSION: Identifying SM as a unique clinical entity is essential for diagnosis, prognosis and therapeutic approaches.